منابع مشابه
Tag team at the telomeres
Tag team at the telomeres I t takes two crews of proteins to keep the telomeres in fi ne fettle, as Kim et al. show. TRF1 and TRF2 are just two of the proteins that ensure that a cell's telomeres remain long and structurally sound. Another protein, TIN2, links up with both molecules and with other proteins to form complexes that help maintain the telomeres. However, researchers weren't sure whe...
متن کاملTag team action at the synapse.
Communication between neurons relies on chemical synapses and the release of neurotransmitters into the synaptic cleft. Neurotransmitter release is an exquisitely regulated membrane fusion event that requires the linking of an electrical nerve stimulus to Ca(2+) influx, which leads to the fusion of neurotransmitter-filled vesicles with the cell membrane. The timing of neurotransmitter release i...
متن کاملTag Team Ubiquitin Ligases
Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.
متن کاملTelomeres at a glance.
The linearity of chromosomes creates two major problems for eukaryotic cells: the end-replication problem and the endprotection problem. The end-replication problem stems from the inherent inability of the replication machinery to fully duplicate linear templates. The endprotection problem refers to the propensity of linear chromosome ends to be recognized as DNA double-strand breaks (DSBs). Bo...
متن کاملIt's getting HOT at telomeres.
How telomerase and telomeres are brought together to alleviate telomere shortening and preserve genome integrity in the cell remains incompletely understood. A study in The EMBO Journal now identifies HOT1 as a direct telomere repeat binding protein that contributes to telomerase-mediated telomere elongation, likely by bridging telomere and telomerase interactions. In contrast to the usually ci...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1813iti4